New PDF release: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III),

By Taotao Zou

ISBN-10: 9811006563

ISBN-13: 9789811006562

This thesis makes a speciality of the improvement of gold- and non-classical platinum-based anti-cancer brokers that reveal distinctively assorted anti-cancer mechanisms in comparison to the generally used cisplatin. those steel complexes comprise N-heterocyclic carbene (NHC) ligands that are capable of shape powerful M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. targeted chemical synthesis, in vitro and/or in vivo anti-cancer actions are essentially offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) advanced with a combined diphosphine and bis(NHC) ligand showing favorable balance and displaying major inhibition of tumor development in self sustaining mice versions with out observable uncomfortable side effects; and (iii) a panel of sturdy luminescent cyclometalated platinum(II) complexes showing excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and cellphone apoptosis. those works spotlight the medical power that gold and platinum complexes provide for melanoma treatment.

Show description

Read Online or Download Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) PDF

Best inorganic chemistry books

Download e-book for iPad: Modern Charge-Density Analysis by Carlo Gatti,Piero Macchi

Glossy Charge-Density research specializes in state of the art equipment and purposes of electron-density research. it's a box commonly linked to knowing chemical bonding and the electrostatic houses of subject. lately, it has additionally been concerning predictions of houses and responses of fabrics (having an natural, inorganic or hybrid nature as in smooth fabrics and bio-science, and used for sensible units or biomaterials).

Narayan S. Hosmane's Boron Science: New Technologies and Applications PDF

Boron has made an important effect in our lives via its quiet use in fertilizers, fungicides, soaps, detergents, and heat-resistant glassware. Boron technology: New applied sciences and purposes addresses the purposes of boron in chemistry, undefined, medication, and pharmacology through explaining its function in difficulties corresponding to catalysis and hydroboration in addition to its use in superconductors, fabrics, magnetic/nonmagnetic nanoparticles, and clinical purposes together with melanoma remedy.

Download PDF by Minu Gupta Bhowon,Sabina Jhaumeer-Laulloo,Henri Li Kam: Chemistry: The Key to our Sustainable Future

Chemistry: the most important to our Sustainable destiny is a set of chosen contributed papers by means of contributors of the overseas convention on natural and utilized Chemistry (ICPAC 2012) at the topic of “Chemistry: the major for our destiny” held in Mauritius in July 2012. In mild of the numerous contribution of chemistry to profit of mankind, this publication is a suite of contemporary effects generated from study in chemistry and interdisciplinary parts.

Lanthanide Single Molecule Magnets by Jinkui Tang,Peng Zhang PDF

This publication starts by means of supplying simple details on single-molecule magnets (SMMs), masking the magnetism of lanthanide, the characterization and rest dynamics of SMMs and complicated technique of learning lanthanide SMMs. It then systematically introduces lanthanide SMMs starting from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting these SMMs with excessive barrier and blockading temperatures – an procedure that offers a few very worthy signs for the structural beneficial properties had to optimize the contribution of an Ising kind spin to a molecular magnet.

Extra resources for Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses)

Example text

Download PDF sample

Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou


by Mark
4.1

Rated 4.68 of 5 – based on 5 votes