By Taotao Zou
This thesis makes a speciality of the improvement of gold- and non-classical platinum-based anti-cancer brokers that reveal distinctively assorted anti-cancer mechanisms in comparison to the generally used cisplatin. those steel complexes comprise N-heterocyclic carbene (NHC) ligands that are capable of shape powerful M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. targeted chemical synthesis, in vitro and/or in vivo anti-cancer actions are essentially offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) advanced with a combined diphosphine and bis(NHC) ligand showing favorable balance and displaying major inhibition of tumor development in self sustaining mice versions with out observable uncomfortable side effects; and (iii) a panel of sturdy luminescent cyclometalated platinum(II) complexes showing excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and cellphone apoptosis. those works spotlight the medical power that gold and platinum complexes provide for melanoma treatment.
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Extra resources for Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses)
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou